Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.66 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652033 | 0.96 | C5AR1 (0.64) | C5AR1CALM1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL650674 | 0.96 | C5AR1 (0.64) | C5AR1CALM1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL651187 | 0.93 | C5AR1 (0.68) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL653382 | 0.93 | C5AR1 (0.68) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL5135929 | 0.93 | C5AR1 (0.72) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL4767016 | 0.93 | C5AR1 (0.75) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL649255 | 0.91 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL649645 | 0.90 | C5AR1 (0.70) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL1913064 | 0.90 | C5AR1 (0.67) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR | |
| SCHEMBL648372 | 0.90 | C5AR1 (0.70) | C5AR1SMN1; SMN2LMNAL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |