Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.37 |
| ▸ | UBE2M | P61081 | 3/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651024 | 0.92 | C5AR1 (0.47) | C5AR1TSHR | |
| SCHEMBL650105 | 0.90 | C5AR1 (0.46) | C5AR1MEN1KMT2ATRPV4UBE2M | |
| SCHEMBL648704 | 0.90 | C5AR1 (0.42) | C5AR1MEN1KMT2ATRPV4UBE2M | |
| SCHEMBL1915566 | 0.89 | C5AR1 (0.45) | C5AR1MEN1KMT2ATSHR | |
| SCHEMBL648166 | 0.88 | C5AR1 (0.43) | C5AR1MEN1KMT2ATRPV4UBE2M | |
| SCHEMBL650018 | 0.88 | C5AR1 (0.46) | C5AR1TSHR | |
| SCHEMBL5136743 | 0.88 | C5AR1 (0.45) | C5AR1MEN1KMT2ATRPV4UBE2M | |
| SCHEMBL649523 | 0.87 | MEN1 (0.46) | C5AR1MEN1KMT2ATRPV4P2RX3 | |
| SCHEMBL5137122 | 0.87 | MEN1 (0.46) | C5AR1MEN1KMT2ATRPV4P2RX3 | |
| SCHEMBL651067 | 0.87 | C5AR1 (0.42) | C5AR1MEN1KMT2ATRPV4UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |