⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4408605 | 0.76 | — | — | |
| SCHEMBL9507463 | 0.76 | — | — | |
| SCHEMBL3678406 | 0.76 | — | — | |
| SCHEMBL4890374 | 0.76 | — | — | |
| SCHEMBL9505719 | 0.76 | — | — | |
| SCHEMBL9506482 | 0.76 | — | — | |
| SCHEMBL8773565 | 0.76 | — | — | |
| SCHEMBL3389211 | 0.76 | — | — | |
| SCHEMBL10828114 | 0.76 | — | — | |
| SCHEMBL7784042 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | claimed |
| EP-2710119-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | Cleave Biosciences, Inc. (US) | 2014-03-26 | — | — | EP | claimed |
| WO-2012158435-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | ZHOU HAN-JIE (US) | 2012-11-22 | — | — | WO | claimed |
| US-11925690-B2 | Bifunctional molecules for targeting Rpn11 | AMPHISTA THERAPEUTICS LIMITED (GB) | 2024-03-12 | — | — | US | disclosed |
| US-11690923-B2 | Multinuclear complexes and their preparation | UNIVERSITY OF THE FREE STATE (ZA) | 2023-07-04 | — | — | US | disclosed |
| US-20230076415-A1 | METHODS AND COMPOSITIONS FOR TREATING MELANOMA | UNIVERSITE COTE D'AZUR - GRAND CHÂTEAU (FR) | 2023-03-09 | — | — | US | disclosed |
| EP-4090770-A1 | METHODS AND COMPOSITIONS FOR TREATING MELANOMA | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2022-11-23 | — | — | EP | disclosed |
| US-20210393813-A1 | MULTINUCLEAR COMPLEXES AND THEIR PREPARATION | UNIVERSITY OF THE FREE STATE (ZA) | 2021-12-23 | — | — | US | disclosed |
| EP-3704082-B1 | MULTINUCLEAR COMPLEXES AND THEIR PREPARATION | UNIV FREE STATE (ZA) | 2021-12-15 | — | — | EP | disclosed |
| EP-3807272-A1 | BIFUNCTIONAL MOLECULES FOR TARGETING RPN11 | Amphista Therapeutics Ltd (GB) | 2021-04-21 | — | — | EP | disclosed |
| CN-112533918-A | Bifunctional molecules for targeting Rpn11 | 安菲斯塔治疗有限责任公司 | 2021-03-19 | — | — | CN | disclosed |
| WO-2005014664-A1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014601-A2 | PROCESS FOR THE PREPARATION OF A POLYOLEFIN | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005014666-A1 | PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND | DSM IP ASSETS B.V. (NL) | 2005-02-17 | — | — | WO | disclosed |
| EP-1506974-A1 | Process for the preparation of a metalloorganic compound comprising at least one imine ligand | DSM IP Assets B.V. (NL) | 2005-02-16 | — | — | EP | disclosed |
| EP-1390364-B1 | ARYL-8-AZABICYCLO 3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1390364-A1 | ARYL-8-AZABICYCLO 3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION | Wyeth (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6632824-B2 | Have the ability to act at the 5-HT transporter. | WYETH | 2003-10-14 | — | — | US | disclosed |
| US-20030032645-A1 | Aryl-8-azabicyclo [3.2.1] octanes for the treatment of depression | WYETH | 2003-02-13 | — | — | US | disclosed |
| WO-2002096906-A1 | ARYL-8-AZABICYCLO[3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-12-05 | — | — | WO | disclosed |