Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648891 | 0.95 | C5AR1 (0.44) | C5AR1TSHRPPARGPPARAKDM4E | |
| SCHEMBL648409 | 0.93 | C5AR1 (0.42) | C5AR1TSHRPPARGPPARAKDM4E | |
| SCHEMBL5134747 | 0.92 | C5AR1 (0.42) | C5AR1TSHRPPARGPPARAKDM4E | |
| SCHEMBL1915451 | 0.91 | C5AR1 (0.41) | C5AR1TSHRPPARGPPARAKDM4E | |
| SCHEMBL649513 | 0.91 | C5AR1 (0.43) | C5AR1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL650099 | 0.90 | C5AR1 (0.43) | C5AR1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL650869 | 0.89 | C5AR1 (0.45) | C5AR1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL650095 | 0.88 | C5AR1 (0.39) | C5AR1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL648764 | 0.88 | C5AR1 (0.40) | C5AR1TSHRBACE1CRHR1 | |
| SCHEMBL648305 | 0.88 | C5AR1 (0.41) | C5AR1TSHRPPARGALDH1A1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |