Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.65 |
| ▸ | VEGFA | P15692 | 10/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598863 | 0.83 | EGLN1 (0.63) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL273704 | 0.79 | EGLN1 (1.00) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL271708 | 0.78 | EGLN1 (0.54) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL14900099 | 0.78 | EGLN1 (0.69) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL19158006 | 0.77 | EGLN1 (0.55) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL12598814 | 0.74 | EGLN1 (0.68) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL272116 | 0.72 | VEGFA (0.85) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL272076 | 0.72 | VEGFA (0.85) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL17340651 | 0.71 | EGLN1 (0.58) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL16281890 | 0.71 | EGLN1 (0.60) | EGLN1VEGFAHTTKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2853265-B1 | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha | AERPIO THERAPEUTICS INC (US) | 2017-07-26 | — | — | EP | disclosed |