Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 20/20 | 0.82 |
| ▸ | AKT1 | P31749 | 11/20 | 0.69 |
| ▸ | AKT2 | P31751 | 5/20 | 0.66 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.66 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19158362 | 0.91 | RPS6KB1 (0.82) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL14782367 | 0.90 | RPS6KB1 (1.00) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19158338 | 0.87 | RPS6KB1 (0.80) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19158390 | 0.85 | RPS6KB1 (0.81) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19158136 | 0.85 | RPS6KB1 (0.81) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19158748 | 0.84 | RPS6KB1 (0.82) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19158414 | 0.84 | RPS6KB1 (0.81) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19157744 | 0.84 | RPS6KB1 (0.81) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19158233 | 0.83 | RPS6KB1 (0.81) | RPS6KB1AKT1AKT2AKT3CYP2B6 | |
| SCHEMBL19157659 | 0.83 | RPS6KB1 (0.82) | RPS6KB1AKT1AKT2AKT3CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755965-B1 | NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |