Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 6/20 | 0.40 |
| ▸ | STK17B | O94768 | 3/20 | 0.40 |
| ▸ | ULK1 | O75385 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289710 | 0.89 | CHEK1 (0.46) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL1918007 | 0.87 | CHEK1 (0.43) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL3284549 | 0.87 | CHEK1 (0.43) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL3285334 | 0.85 | STK17A (0.42) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL3283735 | 0.84 | KDR (0.43) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL1918469 | 0.83 | CHEK1 (0.42) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL1917556 | 0.81 | PTK2 (0.43) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL1917545 | 0.79 | JAK3 (0.49) | STK17ASTK17BULK1PTK2PTK2B | |
| SCHEMBL3284100 | 0.79 | PTK2 (0.47) | ULK1PTK2PTK2BJAK3CYP1A2 | |
| SCHEMBL1918200 | 0.78 | PTK2 (0.42) | STK17ASTK17BULK1PTK2PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332924-A1 | Pyrimidine derivates, medicaments comprising them, their use and process of their preparation | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-06-15 | — | — | EP | disclosed |