Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 8/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191022 | 0.92 | GCK (0.44) | GRM5GCKSCDTRPV4SMARCA2 | |
| SCHEMBL12305664 | 0.91 | GAA (0.48) | GRM5GCKSCDTRPV4SMARCA2 | |
| Hydrochloric Acid SCHEMBL190606 | 0.90 | GAA (0.47) | GRM5GCKSCDTRPV4SMARCA2 | |
| SCHEMBL190070 | 0.84 | GCK (0.58) | GRM5GCKNPC1RAB9A | |
| SCHEMBL2740569 | 0.83 | GRM5 (0.41) | GRM5GCKSCD | |
| Hydrochloric Acid SCHEMBL190882 | 0.83 | GRM5 (0.41) | GRM5GCKSCD | |
| Hydrochloric Acid SCHEMBL192190 | 0.83 | GRM5 (0.41) | GRM5GCKSCD | |
| SCHEMBL190444 | 0.82 | MAPT (0.48) | GRM5TRPV4SMARCA2SMARCA4GAA | |
| SCHEMBL190404 | 0.82 | GCK (0.46) | GRM5GCKTRPV4GAANPC1 | |
| SCHEMBL191828 | 0.81 | GCK (0.54) | GRM5GCKSCDTRPV4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |