Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 18/20 | 0.54 |
| ▸ | ALB | P02768 | 2/20 | 0.54 |
| ▸ | BCL2 | P10415 | 6/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19178590 | 0.90 | MCL1 (0.53) | MCL1ALBBCL2BCL2L1 | |
| SCHEMBL4165201 | 0.90 | MCL1 (0.65) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19179113 | 0.90 | MCL1 (0.54) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19180475 | 0.90 | MCL1 (0.52) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL19179232 | 0.89 | MCL1 (0.53) | MCL1ALBBCL2BCL2L1 | |
| SCHEMBL19178549 | 0.87 | MCL1 (0.52) | MCL1ALBBCL2BCL2L1 | |
| SCHEMBL19179107 | 0.87 | MCL1 (0.53) | MCL1ALBBCL2BCL2L1 | |
| SCHEMBL19179146 | 0.86 | MCL1 (0.54) | MCL1ALBBCL2BCL2L1 | |
| SCHEMBL4153871 | 0.80 | MCL1 (0.64) | MCL1ALBBCL2BCL2L1BAD | |
| SCHEMBL4168892 | 0.80 | MCL1 (0.64) | MCL1ALBBCL2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134684-B1 | 7-SUBSTITUTED INDOLE AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2017-08-02 | — | — | EP | claimed |