Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 19/20 | 0.47 |
| ▸ | BCL2 | P10415 | 3/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | NEK4 | P51957 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.44 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.44 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19180605 | 0.89 | MCL1 (0.49) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL4171523 | 0.89 | MCL1 (0.60) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19178791 | 0.87 | MCL1 (0.48) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19179115 | 0.86 | MCL1 (0.45) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19178634 | 0.86 | MCL1 (0.54) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19178846 | 0.84 | MCL1 (0.55) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19178871 | 0.84 | MCL1 (0.54) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19180459 | 0.83 | MCL1 (0.63) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19180302 | 0.83 | MCL1 (0.52) | MCL1BCL2BCL2L1ALBNEK4 | |
| SCHEMBL19178551 | 0.83 | MCL1 (0.49) | MCL1BCL2BCL2L1ALBNEK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134684-B1 | 7-SUBSTITUTED INDOLE AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2017-08-02 | — | — | EP | claimed |