Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCD | Q05655 | 4/20 | 0.57 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.57 |
| ▸ | CAMK2G | Q13555 | 4/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 17/20 | 0.55 |
| ▸ | NEK4 | P51957 | 3/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19178836 | 0.93 | PRKCD (0.56) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19180340 | 0.91 | PRKCD (0.56) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL4154220 | 0.89 | MCL1 (0.71) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL4154215 | 0.89 | MCL1 (0.71) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19179194 | 0.88 | MCL1 (0.65) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19178843 | 0.85 | PRKCD (0.63) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19180419 | 0.84 | MCL1 (0.74) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19178686 | 0.84 | MCL1 (0.60) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19180409 | 0.84 | MCL1 (0.64) | PRKCDCAMK2BCAMK2GAURKBMCL1 | |
| SCHEMBL19180332 | 0.84 | MCL1 (0.57) | PRKCDCAMK2BCAMK2GAURKBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134684-B1 | 7-SUBSTITUTED INDOLE AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2017-08-02 | — | — | EP | claimed |