Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 9/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14846690 | 1.00 | CHKA (0.52) | CHKACA2NCF1PRMT6KDM4E | |
| SCHEMBL19179414 | 0.96 | HDAC6 (0.48) | CHKAHDAC6POLBRAB9AACACB | |
| SCHEMBL14846692 | 0.96 | HDAC6 (0.48) | CHKAHDAC6POLBRAB9AACACB | |
| SCHEMBL19179075 | 0.90 | HRH3 (0.49) | KDM4EHDAC6HRH3POLBRAB9A | |
| SCHEMBL14847021 | 0.90 | HRH3 (0.49) | KDM4EHDAC6HRH3POLBRAB9A | |
| SCHEMBL19179061 | 0.86 | POLB (0.49) | HRH3POLBRAB9AACACB | |
| SCHEMBL14847041 | 0.86 | POLB (0.49) | HRH3POLBRAB9AACACB | |
| SCHEMBL19179541 | 0.84 | POLB (0.47) | POLBRAB9A | |
| SCHEMBL21774487 | 0.84 | POLB (0.47) | POLBRAB9A | |
| SCHEMBL14846679 | 0.83 | HRH3 (0.49) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771337-B1 | 3-(PYRIMIDIN-4-YL)-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH | NOVARTIS AG (CH) | 2017-08-02 | — | — | EP | disclosed |