Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20604877 | 0.82 | PARP1 (0.58) | PARP1RPS6KA3 | |
| SCHEMBL16150439 | 0.82 | PARP1 (0.47) | PARP1RPS6KA3 | |
| SCHEMBL16151304 | 0.79 | PARP1 (0.48) | PARP1RPS6KA3 | |
| SCHEMBL19188530 | 0.79 | PARP1 (0.51) | PARP1 | |
| SCHEMBL16151230 | 0.78 | PARP1 (0.47) | PARP1RPS6KA3 | |
| SCHEMBL30220632 | 0.76 | PARP1 (0.55) | PARP1 | |
| SCHEMBL30172384 | 0.75 | RPS6KA3 (0.53) | PARP1RPS6KA3 | |
| SCHEMBL1393632 | 0.75 | RPS6KA3 (0.53) | PARP1RPS6KA3 | |
| SCHEMBL26581235 | 0.75 | CYP2D6 (0.39) | PARP1 | |
| SCHEMBL15564154 | 0.73 | PARP1 (0.45) | PARP1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| EP-2981538-B1 | PIPERAZINO[1,2-A]INDOL-1-ONES AND [1,4]DIAZEPINO[1,2-A]INDOL-1-ONE | HOFFMANN LA ROCHE (CH) | 2017-08-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | PARP1 230/4885RPS6KA3 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.