Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.42 |
| ▸ | XPO1 | O14980 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991208 | 0.84 | POLB (0.58) | POLBMAOBHTR6GHSRHTR1A | |
| SCHEMBL3160680 | 0.84 | POLB (0.58) | POLBMAOBHTR6GHSRHTR1A | |
| SCHEMBL11375632 | 0.84 | POLB (0.72) | POLBHTR6 | |
| SCHEMBL18577442 | 0.80 | POLB (0.61) | POLBHTR6 | |
| SCHEMBL10132295 | 0.80 | POLB (0.61) | POLBHTR6 | |
| SCHEMBL1443794 | 0.80 | POLB (0.61) | POLBHTR6 | |
| SCHEMBL6990304 | 0.80 | POLB (0.66) | POLBHTR6GHSRHTR1ACYP2D6 | |
| SCHEMBL20828207 | 0.80 | POLB (0.66) | POLBHTR6GHSRHTR1ACYP2D6 | |
| SCHEMBL29813025 | 0.80 | POLB (0.66) | POLBHTR6GHSRHTR1ACYP2D6 | |
| Hydrochloric Acid SCHEMBL7278039 | 0.79 | POLB (0.59) | POLBHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |