Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 17/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724702 | 0.90 | MME (0.44) | MMEACE | |
| SCHEMBL23391076 | 0.90 | MME (0.44) | MMEACE | |
| SCHEMBL17011153 | 0.90 | MME (0.44) | MMEACE | |
| SCHEMBL17409558 | 0.82 | MME (0.46) | MMEACE | |
| SCHEMBL17011206 | 0.78 | MME (0.49) | MMEMMEL1 | |
| SCHEMBL19714984 | 0.74 | MME (0.53) | MMEACE | |
| SCHEMBL19714983 | 0.74 | MME (0.53) | MMEACE | |
| SCHEMBL16199157 | 0.74 | MME (0.53) | MMEACEMMEL1 | |
| SCHEMBL16939240 | 0.73 | MME (0.55) | MMEACE | |
| SCHEMBL17980192 | 0.73 | MME (0.55) | MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3199517-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2017-08-02 | — | — | EP | disclosed |