SCHEMBL1919147

SCHEMBL1919147

Cc1cc(Cl)ccc1-c1ccc(NC(=O)[C@H](Cc2ccc(C(=O)O)cc2)c2ccc(C3CCC(C(C)(C)C)CC3)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GCGR P47871 6/20 0.52
ADCY6 O43306 4/20 0.52
ADCY3 O60266 4/20 0.52
ADCY9 O60503 4/20 0.52
ADCY5 O95622 4/20 0.52
ADCY8 P40145 4/20 0.52
ADCY7 P51828 4/20 0.52
ADCY2 Q08462 4/20 0.52
ADCY1 Q08828 4/20 0.52
ADCY4 Q8NFM4 4/20 0.52
F11 P03951 13/20 0.40
KLKB1 P03952 3/20 0.40
KLK1 P06870 6/20 0.40
ADRB1 P08588 1/20 0.38
ADRB3 P13945 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13494434 1.00 GCGR (0.52) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL13494604 0.91 GCGR (0.48) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL20767742 0.91 GCGR (0.48) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL14659433 0.91 GCGR (0.48) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL20868519 0.87 GCGR (0.55) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL20854837 0.87 GCGR (0.55) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL20495553 0.87 GCGR (0.55) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL13494451 0.87 GCGR (0.55) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL17338906 0.87 GCGR (0.55) GCGRADCY6ADCY3ADCY9ADCY5
SCHEMBL13494455 0.87 GCGR (0.55) GCGRADCY6ADCY3ADCY9ADCY5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11352321-B2 Glucagon antagonists METABASIS THERAPEUTICS, INC. (US) 2022-06-07 US disclosed
US-11352321-B2 Glucagon antagonists METABASIS THERAPEUTICS, INC. (US) 2022-06-07 US disclosed
US-20190330144-A1 GLUCAGON ANTAGONISTS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-10-31 US disclosed
US-20190330144-A1 GLUCAGON ANTAGONISTS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-10-31 US disclosed
US-20190099391-A1 Glucagon Antagonists LIGAND PHARMACEUTICALS, INC. (US) 2019-04-04 US disclosed
US-20190099391-A1 Glucagon Antagonists LIGAND PHARMACEUTICALS, INC. (US) 2019-04-04 US disclosed
US-10221130-B2 Glucagon antagonists METABASIS THERAPEUTICS, INC. (US) 2019-03-05 US disclosed
EP-3153501-B1 GLUCAGON ANTAGONISTS METABASIS THERAPEUTICS INC (US) 2018-11-28 EP disclosed
US-10076504-B2 Glucagon antagonists LIGAND PHARMACEUTICALS, INC. 2018-09-18 US disclosed
US-20180022695-A1 GLUCAGON ANTAGONISTS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2018-01-25 US disclosed
EP-3153501-A1 GLUCAGON ANTAGONISTS Metabasis Therapeutics, Inc. (US) 2017-04-12 EP disclosed
EP-3153501-A1 GLUCAGON ANTAGONISTS Metabasis Therapeutics, Inc. (US) 2017-04-12 EP disclosed
EP-2799428-B1 Glucagon antagonists METABASIS THERAPEUTICS INC (US) 2016-11-16 EP disclosed
US-20150087680-A1 GLUCAGON ANTAGONISTS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-03-26 US disclosed
US-8907103-B2 Glucagon antagonists METABASIS THERAPEUTICS, INC. (US) 2014-12-09 US disclosed
EP-2799428-A2 Glucagon antagonists Metabasis Therapeutics, Inc. (US) 2014-11-05 EP disclosed
EP-2326618-B1 GLUCAGON ANTAGONISTS METABASIS THERAPEUTICS INC (US) 2014-10-15 EP disclosed
US-20130030029-A1 Glucagon Antagonists METABASIS THERAPEUTICS, INC. (US) 2013-01-31 US disclosed
EP-2326618-A1 GLUCAGON ANTAGONISTS Metabasis Therapeutics, Inc. (US) 2011-06-01 EP disclosed
WO-2010019830-A1 GLUCAGON ANTAGONISTS METABASIS THERAPEUTICS, INC. (US) 2010-02-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130030029-A1 Glucagon Antagonists GLP1R, GCG, GCGR GCGR 3/4885ADCY6 417/4885ADCY3 269/4885
US-20190330144-A1 GLUCAGON ANTAGONISTS GLP1R, GCG, GCGR GCGR 3/4885ADCY6 417/4885ADCY3 269/4885
US-20190099391-A1 Glucagon Antagonists GLP1R, GCG, GCGR GCGR 3/4885ADCY6 519/4885ADCY3 273/4885
US-10076504-B2 Glucagon antagonists GLP1R, GCG, GCGR GCGR 3/4885ADCY6 519/4885ADCY3 273/4885
US-11352321-B2 Glucagon antagonists GLP1R, GCG, GCGR GCGR 3/4885ADCY6 417/4885ADCY3 269/4885
US-20150087680-A1 GLUCAGON ANTAGONISTS GLP1R, GCG, GCGR GCGR 3/4885ADCY6 417/4885ADCY3 269/4885
US-20180022695-A1 GLUCAGON ANTAGONISTS GLP1R, GCG, GCGR GCGR 3/4885ADCY6 417/4885ADCY3 269/4885
US-10221130-B2 Glucagon antagonists GLP1R, GCG, GCGR GCGR 3/4885ADCY6 519/4885ADCY3 273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.