Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14832248 | 0.86 | IDH1 (0.75) | IDH1 | |
| SCHEMBL14832249 | 0.86 | IDH1 (0.75) | IDH1 | |
| SCHEMBL19192624 | 0.85 | IDH1 (0.72) | IDH1 | |
| SCHEMBL19192166 | 0.81 | IDH1 (0.55) | IDH1 | |
| SCHEMBL19193207 | 0.81 | IDH1 (0.71) | IDH1 | |
| SCHEMBL19192735 | 0.81 | IDH1 (0.71) | IDH1 | |
| SCHEMBL19193155 | 0.80 | IDH1 (0.71) | IDH1 | |
| SCHEMBL19192779 | 0.80 | IDH1 (0.62) | IDH1 | |
| SCHEMBL19191449 | 0.80 | IDH1 (0.70) | IDH1 | |
| SCHEMBL19191904 | 0.80 | IDH1 (0.71) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771337-B1 | 3-(PYRIMIDIN-4-YL)-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH | NOVARTIS AG (CH) | 2017-08-02 | — | — | EP | disclosed |