Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 18/20 | 0.76 |
| ▸ | FPR2 | P25090 | 10/20 | 0.76 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19192348 | 1.00 | GRM5 (0.76) | GRM5FPR2P2RX7 | |
| SCHEMBL10151945 | 0.95 | GRM5 (0.83) | GRM5FPR2P2RX7 | |
| SCHEMBL11028474 | 0.88 | GRM5 (0.78) | GRM5FPR2P2RX7 | |
| SCHEMBL11942897 | 0.88 | GRM5 (0.78) | GRM5FPR2P2RX7 | |
| SCHEMBL19195096 | 0.88 | GRM5 (0.78) | GRM5FPR2P2RX7 | |
| SCHEMBL11028198 | 0.86 | GRM5 (0.72) | GRM5FPR2P2RX7 | |
| SCHEMBL19192188 | 0.86 | GRM5 (0.83) | GRM5FPR2P2RX7 | |
| SCHEMBL11942892 | 0.86 | GRM5 (1.00) | GRM5FPR2 | |
| SCHEMBL11942902 | 0.86 | GRM5 (0.72) | GRM5FPR2P2RX7 | |
| SCHEMBL9960538 | 0.86 | GRM5 (0.83) | GRM5FPR2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654422-B1 | Bicyclo[3.2.1]octyl amide derivatives as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders | H LUNDBECK AS (DK) | 2017-08-02 | — | — | EP | disclosed |