Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 10/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18742866 | 0.85 | KDM4E (0.40) | EZH2KDM4EALDH1A1ALOX15 | |
| SCHEMBL19193344 | 0.84 | EZH2 (0.44) | EZH2BRD4BAZ2A | |
| SCHEMBL17880817 | 0.83 | EZH2 (0.47) | EZH2 | |
| SCHEMBL16347077 | 0.82 | EZH2 (0.55) | EZH2BRD4BAZ2APOLB | |
| SCHEMBL22401126 | 0.82 | EZH2 (0.55) | EZH2BRD4BAZ2APOLB | |
| SCHEMBL16347078 | 0.82 | EZH2 (0.55) | EZH2BRD4BAZ2APOLB | |
| SCHEMBL16376979 | 0.82 | EZH2 (0.55) | EZH2BRD4BAZ2APOLB | |
| SCHEMBL23682342 | 0.79 | EZH2 (0.55) | EZH2 | |
| SCHEMBL16376978 | 0.79 | EZH2 (0.55) | EZH2 | |
| SCHEMBL29966225 | 0.79 | EZH2 (0.55) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217941-A1 | SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. | 2017-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217941-A1 | SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | BCOR, CYP2B6, AHR | EZH2 1546/4885BRD4 9/4885BAZ2A 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.