Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 1.00 |
| ▸ | JAK3 | P52333 | 20/20 | 1.00 |
| ▸ | JAK1 | P23458 | 18/20 | 1.00 |
| ▸ | JAK2 | O60674 | 14/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565766 | 1.00 | TYK2 (1.00) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL29707875 | 1.00 | TYK2 (1.00) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL18269709 | 1.00 | TYK2 (1.00) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL30569801 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL21574333 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL18269696 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL19469201 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL21229592 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL28414573 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 | |
| SCHEMBL29565829 | 0.88 | TYK2 (0.79) | TYK2JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725470-B2 | Substituted naphthyridines as JAK kinase inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-08-08 | — | — | US | claimed |
| US-10072026-B2 | Crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-09-11 | — | — | US | disclosed |
| US-20170305934-A1 | NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305934-A1 | NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS | JAK1, JAK2, JAK3 | TYK2 6/4885JAK3 3/4885JAK1 1/4885 |
| US-10072026-B2 | Crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile | JAK1, JAK3, MAP3K1 | TYK2 38/4885JAK3 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.