Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 6/20 | 0.70 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19200262 | 0.83 | GRM7 (0.54) | GRM7KCNQ2HRH3MTNR1AMTNR1B | |
| SCHEMBL19200358 | 0.82 | GRM7 (1.00) | GRM7HRH3MTNR1AMTNR1BMAPT | |
| SCHEMBL19200907 | 0.82 | GRM7 (1.00) | GRM7HRH3MTNR1AMTNR1BMAPT | |
| SCHEMBL19200240 | 0.82 | GRM7 (1.00) | GRM7HRH3MTNR1AMTNR1BMAPT | |
| SCHEMBL19200527 | 0.80 | GRM7 (0.53) | GRM7KCNQ2MTNR1AMTNR1BCRHBP | |
| SCHEMBL19183415 | 0.80 | GRM7 (0.53) | GRM7KCNQ2MTNR1AMTNR1BCRHBP | |
| SCHEMBL19183416 | 0.80 | GRM7 (0.53) | GRM7KCNQ2MTNR1AMTNR1BCRHBP | |
| SCHEMBL20678613 | 0.78 | GRM7 (0.51) | GRM7KCNQ2CRHBPCRHR2LMNA | |
| SCHEMBL20678610 | 0.78 | GRM7 (0.51) | GRM7KCNQ2CRHBPCRHR2LMNA | |
| SCHEMBL20678611 | 0.78 | GRM7 (0.51) | GRM7KCNQ2CRHBPCRHR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017131221-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-03 | — | — | WO | disclosed |