Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 5/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19200942 | 1.00 | GRM7 (1.00) | GRM7HRH3NPC1LMNARAB9A | |
| SCHEMBL19200907 | 0.88 | GRM7 (1.00) | GRM7HRH3NPC1LMNARAB9A | |
| SCHEMBL19200240 | 0.88 | GRM7 (1.00) | GRM7HRH3NPC1LMNARAB9A | |
| SCHEMBL19200358 | 0.88 | GRM7 (1.00) | GRM7HRH3NPC1LMNARAB9A | |
| SCHEMBL25464184 | 0.85 | GRM7 (0.73) | GRM7LMNARAB9A | |
| SCHEMBL8225263 | 0.85 | GRM7 (0.73) | GRM7LMNARAB9A | |
| SCHEMBL25464181 | 0.85 | GRM7 (0.73) | GRM7LMNARAB9A | |
| SCHEMBL14011280 | 0.83 | GRM7 (0.71) | GRM7HRH3NPC1LMNARAB9A | |
| SCHEMBL10446634 | 0.82 | GRM7 (0.69) | GRM7KCNQ2POLB | |
| SCHEMBL9515358 | 0.82 | GRM7 (0.69) | GRM7KCNQ2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017131221-A1 | INDANE DERIVATIVES AS MGLUR7 MODULATORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-08-03 | — | — | WO | disclosed |