Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | MC4R | P32245 | 11/20 | 0.43 |
| ▸ | MC1R | Q01726 | 3/20 | 0.42 |
| ▸ | MC5R | P33032 | 3/20 | 0.42 |
| ▸ | MC3R | P41968 | 3/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.41 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180612 | 0.88 | MC4R (0.46) | MC4RMC1RMC5RMC3RKCNQ3 | |
| SCHEMBL1267149 | 0.82 | MC4R (0.50) | TACR1MC4RMC1RMC5RMC3R | |
| SCHEMBL3968947 | 0.82 | MC4R (0.50) | TACR1MC4RMC1RMC5RMC3R | |
| SCHEMBL13493029 | 0.82 | MC4R (0.50) | TACR1MC4RMC1RMC5RMC3R | |
| SCHEMBL12561512 | 0.81 | TACR1 (0.45) | TACR1MC4RMC1RMC5RMC3R | |
| SCHEMBL18914417 | 0.80 | PDE4B (0.59) | TACR1MC4RMC1RMC5RMC3R | |
| SCHEMBL13525795 | 0.80 | PDE4B (0.59) | TACR1MC4RMC1RMC5RMC3R | |
| SCHEMBL13365127 | 0.80 | TACR1 (0.61) | TACR1MC4RKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL13365128 | 0.80 | TACR1 (0.61) | TACR1MC4RKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL13364969 | 0.80 | TACR1 (0.61) | TACR1MC4RKCNQ3KCNQ2KCNQ4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716135-B1 | PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS | PFIZER LTD (GB) | 2011-06-01 | — | — | EP | disclosed |