Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | TEC | P42680 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19202580 | 0.84 | BTK (0.75) | BTKEGFRTECCYP3A4CYP2C9 | |
| SCHEMBL19203225 | 0.84 | BTK (0.64) | BTKEGFRTEC | |
| SCHEMBL19203232 | 0.82 | BTK (0.50) | BTKEGFRTECCYP3A4CYP2C9 | |
| SCHEMBL19202381 | 0.82 | BTK (0.70) | BTKEGFRTEC | |
| SCHEMBL19202386 | 0.82 | BTK (0.70) | BTKEGFRTEC | |
| SCHEMBL19202347 | 0.82 | BTK (0.70) | BTKEGFRTEC | |
| SCHEMBL20573086 | 0.80 | BTK (0.74) | BTK | |
| SCHEMBL20646174 | 0.78 | BTK (0.65) | BTKEGFRTEC | |
| SCHEMBL19202649 | 0.78 | BTK (1.00) | BTKEGFR | |
| SCHEMBL19202349 | 0.78 | BTK (0.65) | BTKEGFRTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409672-B1 | PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES | BEIJING INNOCARE PHARMA TECH CO LTD (CN) | 2021-12-08 | — | — | EP | disclosed |
| WO-2017128917-A1 | PARAZOLE CONDENSED-RING DERIVATIVES AND PREPARATION METHOD THEREOF AND APPLICATION THEREOF IN TREATMENT OF CANCERS, INFLAMMATION AND IMMUNE DISEASES | 北京诺诚健华医药科技有限公司 | 2017-08-03 | — | — | WO | disclosed |