Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17642474 | 0.87 | EGLN1 (0.67) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17642434 | 0.86 | EGLN1 (0.51) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17643591 | 0.85 | EGLN1 (0.67) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17642333 | 0.85 | EGLN1 (0.64) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17642521 | 0.84 | EGLN1 (0.63) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17642490 | 0.81 | EGLN1 (0.60) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL21698845 | 0.81 | EGLN1 (0.59) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17633725 | 0.81 | EGLN1 (1.00) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17634197 | 0.80 | EGLN1 (0.60) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL17642504 | 0.79 | EGLN1 (0.59) | EGLN1ALDH1A1KDM4ESMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197900-B1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME (US) | 2020-02-12 | — | — | EP | disclosed |
| US-9969752-B2 | Inhibitors of HIF prolyl hydroxylase | MERCK SHARP & DOHME CORP. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170233412-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233412-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | HIF1AN, HIF1A, EGLN2 | EGLN1 6/4885ALDH1A1 291/4885KDM4E 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.