Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzyl Alcohol SCHEMBL5861440 | 0.88 | CSNK1E (0.54) | CSNK1ETSHRCNR2DNM1 | |
| Benzyl Alcohol SCHEMBL28859618 | 0.88 | CSNK1E (0.54) | CSNK1ETSHRCNR2DNM1 | |
| Tetradecane SCHEMBL28953562 | 0.87 | TSHR (0.67) | CSNK1ETSHRDNM1EPHX2 | |
| Decane SCHEMBL27277532 | 0.87 | TSHR (0.67) | CSNK1ETSHRDNM1EPHX2 | |
| SCHEMBL5806424 | 0.86 | CSNK1E (0.55) | CSNK1EFFAR4FFAR1CNR2GAA | |
| SCHEMBL10451596 | 0.86 | CSNK1E (0.55) | CSNK1EFFAR4FFAR1CNR2GAA | |
| SCHEMBL9279770 | 0.86 | CSNK1E (0.55) | CSNK1EFFAR4FFAR1CNR2GAA | |
| Benzyl Alcohol SCHEMBL8383587 | 0.86 | CSNK1E (0.51) | CSNK1ETSHRCNR2DNM1EPHX2 | |
| Benzyl Alcohol SCHEMBL8383593 | 0.86 | CSNK1E (0.51) | CSNK1ETSHRCNR2DNM1EPHX2 | |
| SCHEMBL26914633 | 0.86 | CSNK1E (0.55) | CSNK1EFFAR4FFAR1HTR1ATRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411026-A1 | USE OF sGC STIMULATORS FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) | Ironwood Pharmaceuticals, Inc. (US) | 2018-12-12 | — | — | EP | disclosed |
| WO-2017136309-A1 | USE OF sGC STIMULATORS FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-08-10 | — | — | WO | disclosed |