Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 18/20 | 0.59 |
| ▸ | MC3R | P41968 | 7/20 | 0.59 |
| ▸ | MC5R | P33032 | 7/20 | 0.59 |
| ▸ | MC1R | Q01726 | 7/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | PRCP | P42785 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18914642 | 1.00 | MC4R (0.59) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL14598633 | 0.90 | MC4R (0.55) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL20235934 | 0.89 | MC4R (0.48) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL18914510 | 0.89 | MC4R (0.48) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL18914504 | 0.89 | MC4R (0.48) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL18914527 | 0.89 | MC4R (0.49) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL12536886 | 0.88 | MC4R (0.55) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL18914506 | 0.88 | MC4R (0.50) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL18914509 | 0.87 | MC4R (0.49) | MC4RMC3RMC5RMC1RKCNH2 | |
| SCHEMBL18914518 | 0.87 | MC4R (0.49) | MC4RMC3RMC5RMC1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716135-B1 | PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS | PFIZER LTD (GB) | 2011-06-01 | — | — | EP | disclosed |
| US-7649002-B2 | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists | PFIZER INC (US) | 2010-01-19 | — | — | US | disclosed |
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |