Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19836691 | 0.85 | EGFR (0.44) | EGFRCDK4CDK1CCNB1CCND1 | |
| SCHEMBL30580283 | 0.85 | EGFR (0.44) | EGFRCDK4CDK1CCNB1CCND1 | |
| SCHEMBL3449109 | 0.78 | CDK4 (0.51) | EGFRCDK4CDK1CCNB1CCND1 | |
| SCHEMBL19209875 | 0.77 | CDK4 (0.39) | EGFRCDK4CDK1CCNB1CCND1 | |
| SCHEMBL25148843 | 0.73 | CLK2 (0.35) | EGFRCDK4CDK1CCNB1CCND1 | |
| SCHEMBL30406695 | 0.72 | PLK4 (0.41) | EGFRCDK4CCND1CDK6CDK2 | |
| SCHEMBL32685546 | 0.72 | CDK4 (0.36) | EGFRCDK4CCND1PTK2JAK2 | |
| SCHEMBL25198073 | 0.72 | PLK4 (0.41) | EGFRCDK4CCND1CDK6CDK2 | |
| SCHEMBL278830 | 0.72 | CDK2 (0.56) | CDC7CDK4CDK1CCNB1CCND1 | |
| SCHEMBL20987176 | 0.70 | EGFR (0.48) | EGFRCDK4CDK1CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133701-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2017-08-10 | — | — | WO | disclosed |