Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1920512 | 0.90 | MAP2K1 (0.47) | MAP2K1KCNH2CYP2C9CYP2C19MAP2K2 | |
| SCHEMBL1920179 | 0.89 | MAP2K1 (0.50) | MAP2K1KCNH2CYP2C9CYP2C19MAP2K2 | |
| SCHEMBL13015132 | 0.86 | MAP2K1 (0.45) | MAP2K1KCNH2MAP2K2BRAF | |
| SCHEMBL12533858 | 0.84 | MAP2K1 (0.50) | MAP2K1MAP2K2BRAF | |
| SCHEMBL1919943 | 0.83 | BRD4 (0.36) | MAP2K1MAP2K2 | |
| SCHEMBL3777989 | 0.82 | MAP2K2 (0.37) | MAP2K1MAP2K2 | |
| SCHEMBL1920138 | 0.81 | MAP2K1 (0.40) | MAP2K1KCNH2CYP2C9CYP2C19MAP2K2 | |
| SCHEMBL1218952 | 0.80 | MAP2K1 (0.41) | MAP2K1KCNH2CYP2C9CYP2C19MAP2K2 | |
| SCHEMBL12533970 | 0.79 | — | — | |
| SCHEMBL13015135 | 0.78 | MAP2K1 (0.49) | MAP2K1KCNH2CYP2C9CYP2C19MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099796-B1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2011-06-01 | — | — | EP | disclosed |
| US-7855216-B2 | Aza-indolyl compounds and methods of use | GENENTECH, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855216-B2 | Aza-indolyl compounds and methods of use | GENENTECH, INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-20080242655-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2008-10-02 | — | — | US | disclosed |
| US-20080242655-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242655-A1 | AZA-INDOLYL COMPOUNDS AND METHODS OF USE | CDKN1A, MKI67, CCNI | MAP2K1 24/4885KCNH2 2969/4885CYP2C9 2527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.