Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 20/20 | 0.51 |
| ▸ | MC3R | P41968 | 19/20 | 0.51 |
| ▸ | MC1R | Q01726 | 19/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846233 | 0.93 | MC4R (0.50) | MC4RMC3RMC1R | |
| SCHEMBL6334964 | 0.92 | MC4R (0.59) | MC4RMC3RMC1R | |
| SCHEMBL5844342 | 0.89 | MC4R (0.62) | MC4RMC3RMC1R | |
| Trifluoroacetic Acid SCHEMBL5844737 | 0.89 | MC4R (0.57) | MC4RMC3RMC1R | |
| SCHEMBL5844130 | 0.87 | MC4R (0.49) | MC4RMC3RMC1R | |
| SCHEMBL5844886 | 0.86 | MC4R (0.53) | MC4RMC3RMC1R | |
| Hydrochloric Acid SCHEMBL5844431 | 0.86 | MC4R (0.60) | MC4RMC3RMC1R | |
| SCHEMBL6172375 | 0.86 | MC4R (0.60) | MC4RMC3RMC1R | |
| SCHEMBL5846439 | 0.86 | MC4R (0.64) | MC4RMC3RMC1R | |
| SCHEMBL5844511 | 0.85 | MC4R (0.59) | MC4RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220143135-A1 | INHIBITORS OF BCL-2 | UNIV CASE WESTERN RESERVE (US) | 2022-05-12 | — | — | US | disclosed |
| US-11229641-B2 | Inhibitors of Bcl-2 | CASE WESTERN RESERVE UNIVERSITY (US) | 2022-01-25 | — | — | US | disclosed |
| US-20170224678-A1 | INHIBITORS OF BCL-2 | CASE WESTERN RESERVE UNIVERSITY | 2017-08-10 | — | — | US | disclosed |
| US-20170224678-A1 | INHIBITORS OF BCL-2 | CASE WESTERN RESERVE UNIVERSITY | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170224678-A1 | INHIBITORS OF BCL-2 | BCL2, BAX, BAK1 | MC4R 4512/4885MC3R 3741/4885MC1R 4052/4885 |
| US-11229641-B2 | Inhibitors of Bcl-2 | BCL2, BAX, BAK1 | MC4R 4512/4885MC3R 3741/4885MC1R 4052/4885 |
| US-20220143135-A1 | INHIBITORS OF BCL-2 | BCL2, BAX, BAK1 | MC4R 4512/4885MC3R 3741/4885MC1R 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.