SCHEMBL1921390

SCHEMBL1921390

NC(=O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O

nearest known ligand 0.80

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 20/20 0.80
EGLN3 Q9H6Z9 8/20 0.80
VEGFA P15692 6/20 0.80
FLT1 P17948 6/20 0.80
TET3 O43151 1/20 0.80
BBOX1 O75936 1/20 0.80
ASPH Q12797 1/20 0.80
TET2 Q6N021 1/20 0.80
KDM8 Q8N371 1/20 0.80
OGFOD1 Q8N543 1/20 0.80
TET1 Q8NFU7 1/20 0.80
HIF1AN Q9NWT6 1/20 0.80
FTO Q9C0B1 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30239851 1.00 EGLN1 (0.80) EGLN1EGLN3VEGFAFLT1TET3
SCHEMBL4367990 0.92 EGLN1 (0.69) EGLN1EGLN3VEGFAFLT1TET3
Vadadustat SCHEMBL1920738 0.89 EGLN1 (1.00) EGLN1EGLN3VEGFAFLT1TET3
Vadadustat SCHEMBL29405970 0.89 EGLN1 (1.00) EGLN1EGLN3VEGFAFLT1TET3
Vadadustat SCHEMBL29357486 0.89 EGLN1 (1.00) EGLN1EGLN3VEGFAFLT1TET3
SCHEMBL21390798 0.89 EGLN1 (0.82) EGLN1EGLN3VEGFAFLT1TET3
SCHEMBL20711162 0.88 EGLN1 (0.64) EGLN1EGLN3VEGFAFLT1TET3
SCHEMBL15164149 0.88 EGLN1 (0.80) EGLN1EGLN3VEGFAFLT1TET3
SCHEMBL16728915 0.88 EGLN1 (0.80) EGLN1EGLN3VEGFAFLT1TET3
SCHEMBL14308517 0.87 EGLN1 (0.83) EGLN1EGLN3VEGFAFLT1TET3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE47437-E1 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2019-06-18 US claimed
US-20170189387-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE WARNER CHILCOTT COMPANY, LLC (PR) 2017-07-06 US claimed
US-9598370-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2017-03-21 US claimed
US-20160009648-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE KREOS CAPITAL VII (UK) LIMITED (GB) 2016-01-14 US claimed
US-20150119425-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE WARNER CHILCOTT COMPANY, LLC (PR) 2015-04-30 US claimed
US-8940773-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2015-01-27 US claimed
US-20140045899-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE AKEBIA THERAPEUTICS, INC. (US) 2014-02-13 US claimed
US-8598210-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2013-12-03 US claimed
US-20130203816-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE AKEBIA THERAPEUTICS INC. (US) 2013-08-08 US claimed
US-8343952-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS INC. (US) 2013-01-01 US claimed
EP-2044005-B8 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE WARNER CHILCOTT CO LLC (PR) 2012-12-05 EP claimed
US-8323671-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS INC. (US) 2012-12-04 US claimed
EP-2327696-A1 Prolyl hydroxylase inhibitors and methods of use Warner Chilcott Company, LLC (PR) 2011-06-01 EP claimed
US-20100331374-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE AKEBIA THERAPEUTICS, INC. 2010-12-30 US claimed
US-20100331303-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE AKEBIA THERAPEUTICS, INC. 2010-12-30 US claimed
EP-2044005-A2 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE The Procter and Gamble Company (US) 2009-04-08 EP claimed
WO-2008002576-A2 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE THE PROCTER & GAMBLE COMPANY (US) 2008-01-03 WO claimed
US-20070299086-A1 Prolyl hydroxylase inhibitors and methods of use THE PROCTER & GAMBLE COMPANY (US) 2007-12-27 US claimed
US-12478615-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2025-11-25 US disclosed
US-20070299086-A1 Prolyl hydroxylase inhibitors and methods of use THE PROCTER & GAMBLE COMPANY (US) 2007-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100331374-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-12478615-B2 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20160009648-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20070299086-A1 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20130203816-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20100331303-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20140045899-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20150119425-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885
US-20170189387-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A EGLN1 6/4885EGLN3 2/4885VEGFA 117/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.