Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 11/20 | 0.47 |
| ▸ | CDC25A | P30304 | 9/20 | 0.47 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.44 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.44 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.44 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.44 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.44 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.44 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.44 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15874318 | 1.00 | DUSP3 (0.47) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15874317 | 1.00 | DUSP3 (0.47) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15886627 | 1.00 | DUSP3 (0.47) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15886628 | 0.94 | DUSP3 (0.48) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL20260275 | 0.94 | DUSP3 (0.48) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15874368 | 0.94 | DUSP3 (0.48) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15886567 | 0.91 | DUSP3 (0.46) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15874282 | 0.90 | DUSP3 (0.47) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL17273933 | 0.90 | DUSP3 (0.47) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL15874280 | 0.90 | DUSP3 (0.47) | DUSP3CDC25AATP1A1ATP1B1ATP1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10272081-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS (CANADA) INC. (CA) | 2019-04-30 | — | — | US | disclosed |
| US-20180161324-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | AQUINOX PHARMACEUTICALS CANADA INC (CA) | 2018-06-14 | — | — | US | disclosed |
| US-9937167-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS (CANADA) INC. (CA) | 2018-04-10 | — | — | US | disclosed |
| US-20170224682-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | NEOLEUKIN THERAPEUTICS, INC. | 2017-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10272081-B2 | SHIP1 modulators and methods related thereto | PPP1R1B, PPM1A, PPM1D | DUSP3 753/4885CDC25A 499/4885ATP1A1 75/4885 |
| US-20170224682-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | PPP1R1B, PPM1A, PPM1D | DUSP3 753/4885CDC25A 499/4885ATP1A1 75/4885 |
| US-20180161324-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | PPP1R1B, PPM1A, PPM1D | DUSP3 753/4885CDC25A 499/4885ATP1A1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.