Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | KLK7 | P49862 | 2/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19214882 | 0.88 | BACE1 (0.47) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL1573273 | 0.85 | BACE1 (0.45) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL21216444 | 0.85 | BACE1 (0.47) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL19214884 | 0.85 | BACE1 (0.45) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL4736586 | 0.85 | BACE1 (0.45) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL24652808 | 0.85 | BACE1 (0.47) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL19214885 | 0.84 | KLK7 (0.46) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL25364485 | 0.84 | KLK7 (0.46) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL2978399 | 0.83 | BACE1 (0.49) | BACE1BACE2GPR119KLK7STS | |
| SCHEMBL25362188 | 0.83 | KLK7 (0.45) | BACE1BACE2GPR119KLK7STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725442-B2 | Heterocyclic derivative having PGD2 receptor antagonist activity | SHIONOGI & CO., LTD. (JP) | 2017-08-08 | — | — | US | disclosed |