Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19216785 | 0.95 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19216626 | 0.90 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19216964 | 0.90 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19216791 | 0.88 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19216787 | 0.86 | IDH1 (0.82) | IDH1 | |
| SCHEMBL19513892 | 0.82 | IDH1 (0.75) | IDH1 | |
| SCHEMBL19216930 | 0.80 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19216863 | 0.80 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19216665 | 0.78 | IDH1 (1.00) | IDH1 | |
| SCHEMBL28415382 | 0.78 | IDH1 (0.75) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795146-B | Isoxazole derivatives as inhibitors of mutant isocitrate dehydrogenase 1 | 第一三共株式会社 | 2020-06-26 | — | — | CN | claimed |
| EP-3202766-B1 | ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR | DAIICHI SANKYO CO LTD (JP) | 2019-12-25 | — | — | EP | claimed |
| EP-3202766-B1 | ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR | DAIICHI SANKYO CO LTD (JP) | 2019-12-25 | — | — | EP | disclosed |
| EP-3202766-A1 | ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-08-09 | — | — | EP | disclosed |