Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.88 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 7/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16611342 | 0.94 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16727839 | 0.86 | PIK3CA (0.85) | PIK3CAPIK3R1PIK3CBPIK3CDMTOR | |
| SCHEMBL16611569 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL18373136 | 0.82 | PIK3CA (0.86) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16611835 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16730946 | 0.81 | PIK3CA (0.82) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16611681 | 0.81 | PIK3CA (0.86) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16611561 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16611061 | 0.80 | PIK3CA (0.84) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 | |
| SCHEMBL16622899 | 0.78 | PIK3CA (0.81) | PIK3CAPIK3R1PIK3CBPIK3CDRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724352-B2 | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-08 | — | — | US | disclosed |