Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.76 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19216878 | 0.86 | PIK3CA (0.56) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16611564 | 0.86 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16611611 | 0.84 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16611392 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16611391 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL19216996 | 0.79 | PIK3CA (0.75) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16727841 | 0.76 | PIK3CA (0.82) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16727840 | 0.74 | PIK3CA (0.81) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| Risovalisib SCHEMBL16622890 | 0.74 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 | |
| SCHEMBL16713180 | 0.73 | PIK3CA (0.76) | PIK3CAPIK3R1PIK3CDPIK3CBRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724352-B2 | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-08 | — | — | US | disclosed |