Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.43 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845763 | 0.91 | BACE1 (0.42) | BACE1CTSDRORC | |
| SCHEMBL2370915 | 0.83 | BACE1 (0.40) | BACE1RORC | |
| SCHEMBL2370712 | 0.83 | BACE1 (0.40) | BACE1RORC | |
| SCHEMBL15134942 | 0.79 | BACE1 (0.45) | BACE1CTSD | |
| SCHEMBL2370803 | 0.77 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2370799 | 0.77 | BACE1 (0.48) | BACE1CTSD | |
| SCHEMBL2522218 | 0.77 | BACE1 (0.39) | BACE1CTSDRORC | |
| SCHEMBL2522217 | 0.77 | BACE1 (0.39) | BACE1CTSDRORC | |
| SCHEMBL16139658 | 0.75 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL2371827 | 0.73 | BACE1 (0.47) | BACE1CTSDRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725469-B2 | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use | AMGEN, INC. (US) | 2017-08-08 | — | — | US | disclosed |