Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.56 |
| ▸ | CTSD | P07339 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17210421 | 0.91 | BACE1 (0.69) | BACE1 | |
| SCHEMBL17210384 | 0.90 | BACE1 (0.62) | BACE1CTSDBACE2 | |
| SCHEMBL15717732 | 0.88 | BACE1 (0.55) | BACE1CTSDBACE2 | |
| SCHEMBL15719871 | 0.85 | BACE1 (0.49) | BACE1CTSDBACE2 | |
| SCHEMBL15717670 | 0.81 | BACE1 (0.71) | BACE1CTSD | |
| SCHEMBL15717415 | 0.80 | BACE1 (0.70) | BACE1 | |
| SCHEMBL17201837 | 0.80 | BACE1 (0.62) | BACE1CTSDBACE2 | |
| SCHEMBL17201842 | 0.79 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL17201840 | 0.79 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL17210398 | 0.75 | BACE1 (0.47) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725469-B2 | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use | AMGEN, INC. (US) | 2017-08-08 | — | — | US | disclosed |