SCHEMBL19217643

SCHEMBL19217643

CCOP(=O)(OC)OC(C)OC(COc1ccc(CC2SC(=O)N(N)C2=O)cc1)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.40
FFAR1 O14842 5/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6928219 0.82 FFAR1 (0.55) PPARGFFAR1
SCHEMBL14213645 0.81 FFAR1 (0.40) PPARGFFAR1
SCHEMBL6928297 0.76 FFAR1 (0.59) PPARGFFAR1
SCHEMBL14213651 0.74 FFAR1 (0.41) PPARGFFAR1
SCHEMBL19217722 0.73 PPARG (0.37) PPARGFFAR1
SCHEMBL19217752 0.67 PPARG (0.52) PPARGFFAR1
SCHEMBL19559659 0.67 PPARG (0.41) PPARGFFAR1
SCHEMBL19559693 0.67 PPARG (0.41) PPARGFFAR1
SCHEMBL6928255 0.66 PPARG (0.50) PPARGFFAR1
SCHEMBL6928121 0.65 FFAR1 (0.56) PPARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3202401-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES Octeta Therapeutics, LLC (US) 2017-08-09 EP disclosed