Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | MPC2 | O95563 | 2/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928374 | 0.79 | PPARG (0.48) | PPARGFFAR1PPARACYP3A4RXRA | |
| SCHEMBL6929520 | 0.71 | FFAR1 (0.46) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL6602044 | 0.69 | PPARG (0.62) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL16379095 | 0.69 | PPARG (0.64) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL15811532 | 0.69 | PPARG (0.65) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL19217555 | 0.69 | PPARG (0.53) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL19217633 | 0.68 | PPARG (0.53) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL8282032 | 0.68 | PPARG (0.65) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL19217579 | 0.68 | PPARG (0.67) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL2608677 | 0.68 | PPARG (0.67) | PPARGFFAR1PPARACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3202401-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Octeta Therapeutics, LLC (US) | 2017-08-09 | — | — | EP | disclosed |