Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | MPC2 | O95563 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21504792 | 0.91 | PPARG (0.52) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL6929486 | 0.86 | PPARG (0.50) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL19217847 | 0.83 | PPARG (0.58) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL15811625 | 0.82 | FFAR1 (0.54) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL21504870 | 0.82 | FFAR1 (0.54) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL19217893 | 0.82 | FFAR1 (0.54) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL6928255 | 0.80 | PPARG (0.50) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL19217585 | 0.80 | PPARG (0.50) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL6930334 | 0.79 | PPARG (0.52) | PPARGFFAR1PPARACYP3A4MEN1 | |
| SCHEMBL6929520 | 0.77 | FFAR1 (0.46) | PPARGFFAR1PPARACYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3202401-B1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | CIRIUS THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| EP-3202401-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Octeta Therapeutics, LLC (US) | 2017-08-09 | — | — | EP | disclosed |