Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.37 |
| ▸ | MPC2 | O95563 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928222 | 0.88 | PPARG (0.53) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL14213647 | 0.83 | PPARG (0.38) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL19217722 | 0.82 | PPARG (0.37) | PPARGFFAR1ADRB2ADRB3ADRB1 | |
| SCHEMBL16491949 | 0.81 | PPARG (0.51) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL6930345 | 0.80 | PPARG (0.58) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL16489282 | 0.76 | PPARG (0.36) | PPARGFFAR1ADRB2ADRB3 | |
| SCHEMBL16311112 | 0.75 | PPARG (0.56) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL19217568 | 0.75 | PPARG (0.48) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL19217710 | 0.74 | PPARG (0.53) | PPARGFFAR1MPC2CYP2C8CYP2C9 | |
| SCHEMBL14213653 | 0.73 | PPARG (0.40) | PPARGFFAR1MPC2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3202401-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Octeta Therapeutics, LLC (US) | 2017-08-09 | — | — | EP | disclosed |