Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2032777 | 0.89 | BRD9 (0.35) | ADRA2CBRD4BRD9ABL1 | |
| SCHEMBL1922278 | 0.87 | AVPR2 (0.32) | BRD4BRD9AVPR2AVPR1A | |
| SCHEMBL1924064 | 0.86 | NAMPT (0.34) | BRD4BRD9ABL1GRM5 | |
| SCHEMBL1922613 | 0.84 | HRH3 (0.30) | BRD4BRD9 | |
| SCHEMBL1921947 | 0.82 | AVPR2 (0.32) | BRD4BRD9ABL1AVPR2AVPR1A | |
| SCHEMBL2025699 | 0.82 | BRD9 (0.35) | BRD4BRD9ABL1GRM5 | |
| SCHEMBL303148 | 0.80 | JAK2 (0.44) | BRD4BRD9 | |
| SCHEMBL1922118 | 0.79 | NAMPT (0.34) | BRD4BRD9ABL1GRM5 | |
| SCHEMBL2030372 | 0.79 | NAMPT (0.34) | BRD4BRD9ABL1GRM5 | |
| SCHEMBL2028548 | 0.79 | NAMPT (0.34) | BRD4BRD9ABL1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328871-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | disclosed |