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SCHEMBL1921928

SCHEMBL1921928

C[C@@H]1CN(C(=O)[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2c2ccc(F)cc2F)C[C@H](C)[C@]1(O)c1ccc(F)c(F)c1

nearest known ligand 0.75

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ MC4R P32245 20/20 0.75
▸ MC5R P33032 7/20 0.65
▸ MC3R P41968 5/20 0.65
▸ MC1R Q01726 3/20 0.65
▸ KCNH2 Q12809 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13525805 1.00 MC4R (0.75) MC4RMC5RMC3RMC1RKCNH2
SCHEMBL13525786 0.94 MC4R (0.74) MC4RMC5RMC3RMC1RKCNH2
SCHEMBL13525797 0.90 MC4R (0.75) MC4RMC5RMC3RMC1RKCNH2
SCHEMBL13525804 0.90 MC4R (0.75) MC4RMC5RMC3RMC1RKCNH2
SCHEMBL3166747 0.87 MC4R (0.77) MC4RMC5RMC3RMC1RKCNH2
SCHEMBL3166754 0.87 MC4R (0.77) MC4RMC5RMC3RMC1RKCNH2
SCHEMBL13525590 0.86 MC4R (1.00) MC4RMC5RMC3RMC1RKCNH2
Hydrochloric Acid SCHEMBL1920846 0.85 MC4R (1.00) MC4RMC5RMC3RMC1RKCNH2
Hydrochloric Acid SCHEMBL1920844 0.85 MC4R (1.00) MC4RMC5RMC3RMC1RKCNH2
Hydrochloric Acid SCHEMBL4667236 0.85 MC4R (1.00) MC4RMC5RMC3RMC1RKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1716135-B1 PIPERIDINYLCARBONYL-PYRROLIDINES AND THEIR USE AS MELANOCORTIN AGONISTS PFIZER LTD (GB) 2011-06-01 — — EP disclosed