Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.60 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11973757 | 0.91 | MME (0.70) | MMEMMP2MMP3ACECTSK | |
| SCHEMBL20099589 | 0.91 | MME (0.70) | MMEMMP2MMP3ACECTSK | |
| SCHEMBL11969971 | 0.91 | MME (0.70) | MMEMMP2MMP3ACECTSK | |
| SCHEMBL20306289 | 0.86 | MME (0.60) | MMEMMP2MMP3ACECTSK | |
| SCHEMBL11969628 | 0.81 | MME (0.56) | MMEMMP2MMP3ACECTSK | |
| SCHEMBL16930454 | 0.80 | MME (0.55) | MMEACEMMEL1ALDH1A1MAPT | |
| SCHEMBL20578496 | 0.80 | MME (0.55) | MMEACEMMEL1ALDH1A1MAPT | |
| SCHEMBL18874680 | 0.80 | MME (0.55) | MMEACEMMEL1ALDH1A1MAPT | |
| SCHEMBL11970064 | 0.80 | MME (0.54) | MMEACECTSKCTSSSCN9A | |
| SCHEMBL11969730 | 0.80 | MME (0.54) | MMEACECTSKCTSSSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724359-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-08-08 | — | — | US | disclosed |