Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812469 | 1.00 | CDC7 (0.49) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL4812460 | 1.00 | CDC7 (0.49) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL10233522 | 0.86 | CDC7 (0.48) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL17344039 | 0.81 | ESR1 (0.44) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL15907429 | 0.81 | ESR1 (0.44) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL21996579 | 0.81 | ESR1 (0.44) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL15901289 | 0.81 | ESR1 (0.36) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL15901290 | 0.81 | ESR1 (0.36) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL15903709 | 0.81 | ESR1 (0.36) | CDC7ROCK2MAP4K4PIM1PRKACA | |
| SCHEMBL19154377 | 0.80 | ESR1 (0.35) | CDC7ROCK2MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948452-B1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-08-09 | — | — | EP | disclosed |