SCHEMBL19225641

SCHEMBL19225641

C[C@H](Oc1cc(C(=O)NC(C)(N)C2CC2)ncc1Br)C(F)(F)F

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 20/20 0.58
CNR1 P21554 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19225458 0.87 CNR2 (0.56) CNR2CNR1
SCHEMBL17308884 0.86 CNR2 (0.52) CNR2CNR1
SCHEMBL19225644 0.86 CNR2 (0.52) CNR2CNR1
SCHEMBL19225457 0.86 CNR2 (0.53) CNR2CNR1
SCHEMBL15790095 0.85 CNR2 (0.54) CNR2CNR1
SCHEMBL15777447 0.85 CNR2 (0.51) CNR2CNR1
SCHEMBL19225453 0.83 CNR2 (0.58) CNR2CNR1
SCHEMBL17308820 0.80 CNR2 (0.80) CNR2CNR1
SCHEMBL19225646 0.80 CNR2 (0.49) CNR2CNR1
SCHEMBL15790197 0.80 CNR2 (0.49) CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2928867-B1 PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS HOFFMANN LA ROCHE (CH) 2017-08-09 EP disclosed