Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 20/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15392081 | 0.92 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL16714110 | 0.82 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL15391437 | 0.81 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL15391879 | 0.80 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL16714133 | 0.79 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL15392364 | 0.79 | ABL1 (0.77) | ABL1KCNH2 | |
| SCHEMBL19225995 | 0.78 | ABL1 (0.86) | ABL1KCNH2 | |
| SCHEMBL16714108 | 0.78 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL16714106 | 0.78 | ABL1 (1.00) | ABL1KCNH2 | |
| SCHEMBL15391043 | 0.78 | ABL1 (1.00) | ABL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900637-B1 | THIAZOLE OR IMIDAZOLE SUBSTITUTED PYRIMIDINE, PYRIDINE AND PYRAZINE AMIDE DERIVATIVES AND RELATED COMPOUNDS AS ABL1, ABL2 AND BCR-ABL1 INHIBITORS FOR THE TREATMENT OF CANCER, SPECIFIC VIRAL INFECTIONS AND SPECIFIC CNS DISORDERS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | disclosed |