Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376305 | 0.88 | IRAK4 (0.45) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL3230955 | 0.82 | IRAK4 (0.47) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL3230154 | 0.82 | IRAK4 (0.47) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL376488 | 0.77 | IRAK4 (0.53) | IRAK4FLT3MAPK8MAPK9PKM | |
| SCHEMBL376306 | 0.76 | IRAK4 (0.44) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL3233009 | 0.74 | MAPK8 (0.44) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL15203433 | 0.74 | MAPK8 (0.44) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL2035069 | 0.74 | IRAK4 (0.54) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL10239848 | 0.72 | IRAK4 (0.64) | IRAK4FLT3MAPK8MAPK9MAPK10 | |
| SCHEMBL376539 | 0.72 | IRAK4 (0.40) | IRAK4FLT3MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518952-B2 | 6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors | PFIZER INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2328890-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | Pfizer Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010016005-A1 | 6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS | PFIZER INC. (US) | 2010-02-11 | — | — | WO | disclosed |