Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 17/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | OGA | O60502 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588422 | 1.00 | HRH4 (1.00) | HRH4HRH3ADRA2BADRA2CSLC6A2 | |
| SCHEMBL847961 | 0.86 | HRH4 (1.00) | HRH4HRH3RET | |
| SCHEMBL1588054 | 0.82 | HRH4 (0.85) | HRH4HRH3RET | |
| SCHEMBL847364 | 0.82 | HRH4 (0.69) | HRH4HRH3RET | |
| SCHEMBL1587805 | 0.82 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL1588088 | 0.82 | HRH4 (0.91) | HRH4HRH3RET | |
| SCHEMBL1587803 | 0.82 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL1588231 | 0.82 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL1587994 | 0.81 | HRH4 (0.73) | HRH4HRH3RET | |
| SCHEMBL19459061 | 0.81 | HRH4 (0.73) | HRH4HRH3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9732087-B2 | Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-08-15 | — | — | US | disclosed |